
Fetomaternal Bleed, Flow Cytometry, Blood
2
Overview
In hemolytic disease of the newborn, fetal red blood cells are coated with maternal IgG alloantibodies targeting paternal antigens absent on maternal cells. This leads to accelerated cell destruction before and after birth, with varying clinical severity. Detection may require serological testing of seemingly healthy infants. Pregnancy triggers immunization via fetomaternal hemorrhage (FMH), occurring in up to 75% of pregnancies, often around delivery. Rh immune globulin (RhIG) is administered to Rh-negative mothers carrying Rh-positive fetuses to prevent maternal immune response. RhIG dosage depends on FMH volume, occurring during various obstetric procedures and trauma.
METHOD NAME
Flow Cytometry
AVAILABILITY
TBC
REPORTING NAME
Fetomaternal Bleed,Flow Cytometry,B
ALIASES
Fetal Hemoglobin
Fetal Maternal Bleed
Fetal Maternal Erythrocyte Distribution, Blood
Fetal Red Cells for Fetal Maternal Erythrocyte Distribution
Fetal-Maternal Erythrocyte Differentiation
Kleihauer Acid Elution (Fetal RBC's)
Kleihauer-Betke
Maternal Erythrocyte Diff