&lt;h1 id=&quot;firstHeading&quot; class=&quot;firstHeading&quot; lang=&quot;en&quot;&gt;ass juice&lt;/h1&gt;
&lt;div id=&quot;bodyContent&quot; class=&quot;mw-body-content&quot;&gt;
&lt;div id=&quot;mw-content-text&quot; class=&quot;mw-content-ltr&quot; dir=&quot;ltr&quot; lang=&quot;en&quot;&gt;
&lt;div class=&quot;mw-parser-output&quot;&gt;
&lt;h2&gt;&lt;span class=&quot;mw-headline&quot;&gt;Noun&amp;nbsp;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;strong class=&quot;Latn headword&quot; lang=&quot;en&quot;&gt;ass&amp;nbsp;juice&lt;/strong&gt;&amp;nbsp;&lt;span style=&quot;color: #99ccff;&quot;&gt;(&lt;em&gt;usually&amp;nbsp;uncountable&lt;/em&gt;,&amp;nbsp;&lt;em&gt;plural&lt;/em&gt;&amp;nbsp;&lt;/span&gt;&lt;strong class=&quot;Latn form-of lang-en p-form-of&quot; lang=&quot;en&quot;&gt;ass juices&lt;/strong&gt;)&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Semen, saliva, other fluid lubricant mixed with rectal mucous produced in the rectum present in the rectum during or after anal sex.&lt;/span&gt;&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;&lt;strong&gt;The Rectum&lt;/strong&gt;&amp;nbsp;&lt;span style=&quot;color: #99ccff;&quot;&gt;is the distal part of the&amp;nbsp;large intestine&amp;nbsp;between the sigmoid&amp;nbsp;colon&amp;nbsp;and the&amp;nbsp;anal canal.&amp;nbsp;In Latin, the word &amp;ldquo;rectum&amp;rdquo; means straight.&amp;nbsp;The distension of the rectum begins the urge to defecate.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;img src=&quot;https://www.earthslab.com/wp-content/uploads/2017/07/Rectum.jpg&quot; alt=&quot;Rectum: Location&quot; /&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The rectum is 5 inches (12 cm) long. The diameter of the rectum isn&amp;rsquo;t uniform throughout. In the upper part, the rectum is 4cm. In the lower part, &lt;span style=&quot;text-decoration: underline;&quot;&gt;rectum creates a dilatation&lt;/span&gt; so it can stretch.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;How the rectum extend is as under:&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;In the upper third- rectum is pointed downward and backward.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;In the middle third- rectum is directed vertically downward.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;In the lower third- rectum is pointed downward and forward.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The rectum can absorb water from your poop.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;div class=&quot;block_body&quot;&gt;&amp;nbsp;
&lt;h2 id=&quot;content-inside-of-the-rectum&quot; class=&quot;ftwp-heading&quot;&gt;INSIDE OF THE RECTUM&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The inner part of the rectum presents 2 types of mucosalfolds- temporary and long-lasting.&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Temporary folds are mainly longitudinal and seen in thelower part of the rectum. They evaporate when rectum distends.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Long-Term folds (or Houston&amp;rsquo;s valves) are semilunar (crescentic) transverse folds situated against the concavities of the lateral curvatures of the rectum. They&amp;rsquo;re created by the reduplication of the mucous membrane consisting of submucous tissue and thickening of circular smooth muscle of the rectal wall.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;h2&gt;&lt;span class=&quot;mw-headline&quot;&gt;The Five Layers of the rectal wall&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The rectal wall consists of five distinct layers, namely&lt;/span&gt;&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;the&amp;nbsp;&lt;strong&gt;mucosa&lt;/strong&gt;&amp;nbsp;(lined by columnar epithelium with a lot of mucous-producing goblet cells)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;deep&amp;nbsp;&lt;strong&gt;mucosa&lt;/strong&gt;&amp;nbsp;(&lt;strong&gt;lamina propria&lt;/strong&gt;&amp;nbsp;and&amp;nbsp;&lt;strong&gt;muscularis mucosae&lt;/strong&gt;)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;submucosa&lt;/strong&gt;&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;muscularis propria&lt;/strong&gt;&amp;nbsp;(2 thick proper muscle layers; inner circular and outer longitudinal layers)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;serosa&lt;/strong&gt;&amp;nbsp;(perirectal fat).&lt;/span&gt;&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;&lt;img src=&quot;https://cdn.britannica.com/19/74319-050-A0139604/intestine-rectum-Structures-human-crypts-mucosa-anus.jpg&quot; alt=&quot;Anus | anatomy | Britannica&quot; width=&quot;815&quot; height=&quot;725&quot; /&gt;&lt;/p&gt;
&lt;h2&gt;&lt;span class=&quot;mw-headline&quot;&gt;The Secret of Goblet Cells&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;There are plenty of Goblet Cells lining the mucosal layer of the rectal wall&lt;/span&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;These Goblet cells are a specialized type of epithelial cell that&lt;/span&gt; &lt;span style=&quot;text-decoration: underline;&quot;&gt;&lt;strong&gt;secrete mucins&lt;/strong&gt;&lt;/span&gt;, &lt;span style=&quot;color: #99ccff;&quot;&gt;which are significant components of mucus &amp;ndash; a gel-like secretion.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Mucins are highly glycosylated proteins, which means they have many carbohydrate residues attached to their structure. These carbohydrates give mucus its slimy, gel-like consistency.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Goblet cells work to produce and secreting mucus helping to lubricate increasingly dry poop on the way out of the GI tract.&lt;/span&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Mucus is important throughout the gastrointestinal tract for lubricating the surfaces of the tissues that materials must slide down (or up and down as you fuck or fist).&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;img src=&quot;https://v1.nitrocdn.com/bvIhcJyiWKFqlMsfAAXRLitDZjWdRlLX/assets/static/source/rev-e8a1fe8/wp-content/uploads/2020/06/Mucus_production_goblet_cells_.jpg&quot; alt=&quot;Goblet Cells&quot; width=&quot;313&quot; height=&quot;250&quot; /&gt;&amp;nbsp;&lt;img src=&quot;https://upload.wikimedia.org/wikipedia/commons/thumb/b/b8/Histopathology_of_goblet_cells_%28annotated%29_and_foveolar_cells_in_incomplete_Barrett%27s_esophagus.jpg/220px-Histopathology_of_goblet_cells_%28annotated%29_and_foveolar_cells_in_incomplete_Barrett%27s_esophagus.jpg&quot; alt=&quot;Goblet cell - Wikipedia&quot; width=&quot;295&quot; height=&quot;249&quot; /&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Histological staining of goblet cells. Cells are stained with the Periodic acid&amp;ndash;Schiff method, which stains the glycoproteins present in mucus a dark purple colour&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Mucous within the Goblet Cells, ready to lubricate your rectum.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;img src=&quot;https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fmi.2015.32/MediaObjects/41385_2015_Article_BFmi201532_Fig1_HTML.jpg&quot; alt=&quot;figure1&quot; /&gt;&lt;/p&gt;
&lt;h2 id=&quot;Sec4&quot; class=&quot;c-article-section__title js-section-title js-c-reading-companion-sections-item&quot;&gt;GOBLET CELLS&lt;/h2&gt;
&lt;div id=&quot;Sec4-content&quot; class=&quot;c-article-section__content&quot;&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Goblet cells are specialized for the synthesis and secretion of mucus. They acquired their name for their typical goblet, cup-like, appearance formed by the mucin granulae that fill up the cytoplasm (&lt;a style=&quot;color: #99ccff;&quot; href=&quot;https://www.nature.com/articles/mi201532#Fig1&quot; data-track=&quot;click&quot; data-track-label=&quot;link&quot; data-track-action=&quot;figure anchor&quot;&gt;Figure 1&lt;/a&gt;). They&amp;nbsp;are continuously renewed from the stem cells at the crypt base with normal cell turnover between 3 and 7 days.&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h2 id=&quot;Sec5&quot; class=&quot;c-article-section__title js-section-title js-c-reading-companion-sections-item&quot;&gt;GOBLET CELL SECRETION&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Secretion of mucins can take place in at least two ways: regulated vesicle secretion and compound exocytosis.&lt;/span&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;(1) a low-level, unregulated, and essentially continuous secretion dependent on cytoskeletal movement of&amp;nbsp;secretory granules; and &lt;/span&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;(2) stimulated secretion via regulated&amp;nbsp;exocytosis&amp;nbsp;of granules in response to irritating extracellular stimuli. This second pathway ensures that mucin production and secretion can rapidly be increased.&lt;sup&gt;2&lt;/sup&gt;&amp;nbsp; The goblet cell mucin provides a protective&amp;nbsp;lubricant&amp;nbsp;barrier against shear stress and shields the&amp;nbsp;intestinal mucosa&amp;nbsp;from peptic digestion and chemical damage.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;References:&lt;/span&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Barker, N. Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration.&amp;nbsp;&lt;em&gt;Nat. Rev. Mol. Cell Biol.&lt;/em&gt;&amp;nbsp;&lt;strong&gt;15&lt;/strong&gt;, 19&amp;ndash;33 (2014).&lt;/span&gt;&lt;br /&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Specian, D. &amp;amp; Neutra, M.R. Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine.&amp;nbsp;&lt;em&gt;J. Cell Biol.&lt;/em&gt;&amp;nbsp;&lt;strong&gt;85&lt;/strong&gt;, 626&amp;ndash;640 (1980).&lt;/span&gt;&lt;/p&gt;
&lt;/div&gt;

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