&lt;h2&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;Overview&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;This test panel is designed for two main purposes: first, to analyze newborn screening samples showing elevated levels of branched-chain amino acids; second, to provide ongoing care for individuals diagnosed with maple syrup urine disease (MSUD).&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;The method employed is Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Specimens collected include whole blood, typically obtained via blood spot collection on filter paper. Special care is required during collection and handling to ensure accurate testing, including avoiding EDTA-containing devices, ensuring complete blood spot filling, recording feeding information, allowing proper drying time, and maintaining specimen dryness and protection from heat and sunlight.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;hr /&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;WHAT IS IT USED FOR?&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Reviewing newborn screening samples indicating elevated branched-chain amino acids.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Continuing care for individuals diagnosed with maple syrup urine disease.&#39;&lt;/span&gt;&lt;/p&gt;
&lt;div class=&quot;w-full pt-2 md:pt-0 dark:border-white/20 md:border-transparent md:dark:border-transparent md:w-[calc(100%-.5rem)]&quot;&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;/div&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;METHOD NAME&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Portions of this test are covered by patents held by Quest Diagnostics&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;&lt;br /&gt;AVAILABILITY&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&amp;nbsp;&lt;/h3&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;REPORTING NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Allo-isoleucine, BS&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&amp;nbsp;&lt;/h3&gt;
&lt;h3&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;OTHER NAMES&lt;/strong&gt;&lt;/span&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Branched-Chain Amino Acids (BCAA) Elevations&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Newborn Screen&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Newborn Screening&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Maple Syrup Urine Disease (MSUD)&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Maple Syrup Disease&lt;/span&gt;&lt;/p&gt;

&lt;h3 id=&quot;SpecimenType-title&quot;&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SPECIMEN TYPE&lt;/strong&gt;&amp;nbsp;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Whole blood&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&amp;nbsp;&lt;/h3&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SHIPPING INSTRUCTIONS&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;div class=&quot;flex-1 overflow-hidden&quot;&gt;
&lt;div class=&quot;react-scroll-to-bottom--css-ffwkx-79elbk h-full&quot;&gt;
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&lt;div class=&quot;flex flex-col text-sm pb-9&quot;&gt;
&lt;div class=&quot;w-full text-token-text-primary&quot; dir=&quot;auto&quot; data-testid=&quot;conversation-turn-7&quot;&gt;
&lt;div class=&quot;px-4 py-2 justify-center text-base md:gap-6 m-auto&quot;&gt;
&lt;div class=&quot;flex flex-1 text-base mx-auto gap-3 juice:gap-4 juice:md:gap-6 md:px-5 lg:px-1 xl:px-5 md:max-w-3xl lg:max-w-[40rem] xl:max-w-[48rem] group final-completion&quot;&gt;
&lt;div class=&quot;relative flex w-full flex-col agent-turn&quot;&gt;
&lt;div class=&quot;flex-col gap-1 md:gap-3&quot;&gt;
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&lt;div class=&quot;min-h-[20px] text-message flex flex-col items-start gap-3 whitespace-pre-wrap break-words [.text-message+&amp;amp;]:mt-5 overflow-x-auto&quot; dir=&quot;auto&quot; data-message-author-role=&quot;assistant&quot; data-message-id=&quot;51364005-ca87-4f44-9ae9-16e243c2b60c&quot;&gt;
&lt;div class=&quot;markdown prose w-full break-words dark:prose-invert light&quot;&gt;
&lt;h3&gt;&amp;nbsp;&lt;/h3&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SPECIMEN COLLECTION&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;Supplies:&amp;nbsp;&lt;/strong&gt;Card - Blood Spot Collection (Filter Paper) (T493)&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;Container/Tube:&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;Preferred:&amp;nbsp;&lt;/strong&gt;Blood Spot Collection (Filter Paper)&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;Acceptable:&amp;nbsp;&lt;/strong&gt;Local newborn screening card, Whatman Protein Saver 903 filter paper,&amp;nbsp;PerkinElmer 226filter paper, Munktell filter paper, Postmortem Screening Card&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;Specimen Volume:&lt;/strong&gt;&amp;nbsp;2 Blood spots&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;Collection Instructions:&lt;/span&gt;&amp;nbsp;&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;1. Avoid using devices or capillary tubes with EDTA for specimen collection.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;2. Ensure at least one spot is fully filled and unpunctured.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;3. For patients over 1 year old, consider a fingerstick as an alternative blood collection method.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;4. Include details about the type of feeding on the collection card.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;5. Allow blood to air dry on filter paper at room temperature for a minimum of 3 hours.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;6. Protect the specimen from heat and direct sunlight.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;7. Avoid stacking wet specimens.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;8. Maintain the specimen&#39;s dryness throughout handling and storage.&lt;/span&gt;&lt;/p&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
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Allo-isoleucine, Blood Spot